Method of preparing substituted...

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Reexamination Certificate

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06852857

ABSTRACT:
The present invention provides a method of preparing 4-amino-3-alkylthio-1,2,4-triazine-5-ones of the formula (I):wherein R, R1, R2and R3are as defined herein, the method comprising reacting in the presence of a base and under at least one condition selected from the presence of at least one inorganic compound selected from inorganic sulfites and inorganic bisulfites, an inert gas purge, and an alternating inert gas blanket and vacuum, a 4-amino-3-mercapto-1,2,4-triazin-5-one of the formula (II):wherein R, R1and R2are as defined herein, with an alkylating agent of the formula R3—X, wherein R3and X are as defined herein and collecting the reaction product.

REFERENCES:
patent: 3671523 (1972-06-01), Westphal et al.
patent: 3905801 (1975-09-01), Fawzi
patent: 4035364 (1977-07-01), Dickore et al.
patent: 4131129 (1978-12-01), Firestone
patent: 4175188 (1979-11-01), Klenk et al.
patent: 4309538 (1982-01-01), Schmidt et al.
patent: 4346220 (1982-08-01), Fawzi
patent: 4402733 (1983-09-01), Pissiotas et al.
patent: 5440038 (1995-08-01), Prasad et al.

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