Method of preparing stable sterile ampoules of crystalline cepha

Details Method of preparing stable sterile ampoules of crystalline cepha Method of preparing stable sterile ampoules of crystalline cepha

1977-02-09

1978-08-01

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

53 25, 544 27, A61K 3138, C07D50112

Patent

active

041043910

ABSTRACT:
Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

REFERENCES:
patent: 3085884 (1963-04-01), Morrison
patent: 3614851 (1971-10-01), Green
patent: 3725003 (1973-04-01), Moore et al.

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