Method of preparing stable drug nanoparticles

Details Method of preparing stable drug nanoparticles Method of preparing stable drug nanoparticles

1995-02-09

1996-07-09

Mullis, Jeffrey

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424494, 424497, A61K 914

Patent

active

055342701

ABSTRACT:
Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclaving and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

REFERENCES:
patent: 5399363 (1995-03-01), Liversidge
patent: 5488133 (1996-01-01), Singh et al.

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