Method of preparing rhenium complex using borohydride...

Details Method of preparing rhenium complex using borohydride... Method of preparing rhenium complex using borohydride...

2005-05-03

2005-05-03

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C424S001110

Reexamination Certificate

active

06888019

ABSTRACT:
Disclosed is a method of preparing a rhenium complex by use of a borohydride exchange resin, including dissolving perrhenic acid in a solution containing ethylenediamine tetraacetate, mannitol and stannous chloride to obtain a perrhenic acid solution (step 1), which is then mixed with disulfide in the presence of a borohydride exchange resin and reacts at room temperature, to obtain a rhenium complex (step 2). The preparation method of the current invention is characterized in that rhenium is reduced to have a desired oxidation number through the dissolving of the step 1, whereby the reaction of the step 2 can occur at room temperature. In addition, use of the borohydride exchange resin as a reducing agent results in direct formation of the rhenium complex of sulfide from disulfide, without the need of synthesis of thiol-protected S-precursor. Therefore, radioactive pharmaceuticals having high values can be economically and efficiently produced.

REFERENCES:
patent: 5955053 (1999-09-01), Marzilli et al.
patent: 5986074 (1999-11-01), Marzilli et al.
patent: 6437103 (2002-08-01), Babich et al.
patent: 20030194365 (2003-10-01), Park et al.

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