Method of preparing quinolines, naphthyridines and other nitroge

Details Method of preparing quinolines, naphthyridines and other nitroge Method of preparing quinolines, naphthyridines and other nitroge

1981-07-24

1983-04-19

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546153, 546156, C07D47100, C07D48700, C07D21516, C07D21520

Patent

active

043806325

ABSTRACT:
A method for the preparation of nitrogen bi-heterocyclic compounds is disclosed involving the saponification of a compound of the formula ##STR1## wherein R, E, D, B, A, and R' have the previously assigned significance which comprises saponifying the same by contacting it with at least a stoichiometric amount of water followed by decarboxylation.
The carboxylic acid esters can be those formed by cyclization of dicarboxylic acid esters such as alpha-picolylaminomethylenemalonic acid diethyl ester.

REFERENCES:
patent: 2504874 (1950-04-01), Price et al.
patent: 2504875 (1950-04-01), Price et al.
patent: 3149104 (1964-09-01), Lesher et al.
patent: 3673193 (1972-06-01), Lesher et al.
patent: 3856800 (1974-12-01), Bair
Surrey, A. R. et al., J. American Chem. Soc., 68, (1946) 113-116.
Lin, A. J. et al., Journal of Medicinal Chem., (1978), vol. 21, No. 3, pp. 268-272.

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