Method of preparing purine nucleoside compound

Details Method of preparing purine nucleoside compound Method of preparing purine nucleoside compound

1998-07-23

2000-01-25

Prats, Francisco

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 87, 435 85, 435 72, 536 271, 536 273, 536124, C12P 1940, C12P 1938, C12P 1900, C07H 1916

Patent

active

060177365

ABSTRACT:
The present invention provides a method of preparing stably and at a high yield a purine nucleoside compound by utilizing an exchange reaction of a nucleic acid base which is carried out in the presence of an enzyme, and also provides a microorganism capable of producing uracil thymine dehydrogenase or dihydrouracil dehydrogenase. In preparing the purine nucleoside compound, a pyrimidine nucleoside compound and a purine base are subjected to a base exchange reaction in an aqueous solution containing phosphate ions in the presence of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase. The pyrimidine base formed by the base exchange reaction is converted by a microorganism or an enzyme derived from the microorganism into a compound incapable of acting as substrates of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase so as to obtain a desired product of purine nucleoside compound.

REFERENCES:
Krenitsky et al, Biochemistry 20:3615-3621, 1981.
Chemical Abstracts 127(16):2196SOM, 1997.
Chemical Abstracts 118(23):232397t, 1993.
Chemical Abstracts 117(21):210765p, 1992.
Chemical Abstracts, XP-002084037, vol. 91, No. 25, p. 235, Dec. 17, 1979, abstract no. 206206.

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