Method of preparing polyepitope chimeric gene vaccine

Details Method of preparing polyepitope chimeric gene vaccine Method of preparing polyepitope chimeric gene vaccine

2011-07-19

2011-07-19

Wessendorf, T. D. (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C435S002000, C506S010000, C506S009000, C506S007000, C424S009322, C514S04400A

Reexamination Certificate

active

07981601

ABSTRACT:
The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries of polyepitope chimeric genes with different sizes and lengths using gene shuffling and random assembly so as to screen polyepitope chimeric gene vaccines. Immunization of the body with the gene libraries of the invention results in the induction of high level of specific antibodies and specific types of cytokines, and protection on the body.

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