Method of preparing polyalkylene oxide carboxylic acids

Details Method of preparing polyalkylene oxide carboxylic acids Method of preparing polyalkylene oxide carboxylic acids

1996-08-13

1997-10-28

Gulakowski, Randy

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241791, 525 541, 525403, 525408, 530406, 530410, 560182, 514449, 549433, 549510, C08G 6391, C08L 8900, A61K 3900

Patent

active

056815670

ABSTRACT:
The present invention is directed to methods of preparing high purity polyalkylene oxide carboxylic acids. The methods include reacting a polyalkylene oxide such as polyethylene glycol with a t-butyl haloacetate in the presence of a base followed by treatment with an acid such as trifluoroacetic acid. The resultant polymer carboxylic acids are of sufficient purity so that expensive and time containing purification steps required for pharmaceutical grade polymers are avoided.

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