Method of preparing poly(ADP-ribose) polymerases inhibitors

Details Method of preparing poly(ADP-ribose) polymerases inhibitors Method of preparing poly(ADP-ribose) polymerases inhibitors

2008-01-29

2008-01-29

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

11233845

ABSTRACT:
This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.

REFERENCES:
patent: 6495541 (2002-12-01), Webber et al.
patent: 6934 (2004-06-01), None
patent: WO 00/42040 (2000-07-01), None
patent: PCT/IB2004/000915 (2004-10-01), None

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