Method of preparing photochemotherapic alkylangelicin compounds

Details Method of preparing photochemotherapic alkylangelicin compounds Method of preparing photochemotherapic alkylangelicin compounds

1990-12-27

1993-01-12

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40300

Patent

active

051792176

ABSTRACT:
The alkylangelicins according to the invention are obtained starting from an umbelliferone, in which the 6-position is already substituted by an alkyl group; in such a way the 7-allyloxy or 7-acyloxy umbelliferone intermediates can form by transposition of the allyl or acyl group only the 8-allyl and 8-acyl derivatives, and therefore the presence, even in traces, of psoralens is absolutely excluded in the subsequent synthetic steps.
The 6-alkylangelicins thus obtained are particularly usable for the photochemotherapy of psoriasys and of other skin diseases characterized by cellular hyperproliferation, as well as for the photochemotherapy of vitiligo and of alopecia aerata.

REFERENCES:
patent: 3201421 (1965-08-01), Kaufman
patent: 4312883 (1982-01-01), Bacicheti et al.

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