Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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546 82, 546 83, 546 84, 546134, 546153, 546157, 546119, 546 15, 549341, 560125, 560115, 562507, C07D25504, C07D27301, C07D28500

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045379645

ABSTRACT:
Trans-(.+-.)-1-permissibly-substituted-2,6-dioxodecahydroquinoline or enantiomers thereof, intermediates for preparing tautomeric trans-(.+-.)-5-permissibly substituted octahydro-1H(and 2H)pyrazolo[3,4-g]quinolines, 4aR,8aR or 4aS,8aS enantiomers thereof, for preparing trans-(.+-.)-5-permissibly substituted-octahydropyrazolo (or oxazolo)[4,5-g]quinoline, 4aR,8aR or 4aS,8aS enantiomers thereof or for preparing trans-(.+-.)-6-permissibly-substituted octahydropyrimido[4,5-g]quinolines, a 5aR,9aR or 5aS,9aS enantiomer thereof said racemic intermediates being comprised of stereoisomers of the following formulas ##STR1## wherein R is H, alkyl or C.sub.1-3 straight-chain alkyl.

REFERENCES:
patent: 4198415 (1980-04-01), Kornfeld et al.
March, Advanced Organic Chemistry, 2nd Ed., McGraw-Hill (1977) pp. 346-347; 484-485; 710-711.
March, Advanced Organic Chemistry, 1st Ed., McGraw-Hill (1968), p. 337.
Buehler and Pearson, Survey of Organic Synthesis, 1970, pp. 2,3,4,5.
Bach et al., J. Med. Chem., 23, 481 (1980).
Johnson et al., J. Org. Chem., 33, 3207 (1968).
Momose et al., Chem. Pharm. Bull., 25, 1436 (1977) (Momose I).
Momose et al., ibid, 1797 (Monmose II).
Momose et al., ibid, 26, 620 (1978) (Momose III).

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