Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1984-08-03
1985-08-27
Jiles, Henry R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546 82, 546 83, 546 84, 546134, 546153, 546157, 546119, 546 15, 549341, 560125, 560115, 562507, C07D25504, C07D27301, C07D28500
Patent
active
045379645
ABSTRACT:
Trans-(.+-.)-1-permissibly-substituted-2,6-dioxodecahydroquinoline or enantiomers thereof, intermediates for preparing tautomeric trans-(.+-.)-5-permissibly substituted octahydro-1H(and 2H)pyrazolo[3,4-g]quinolines, 4aR,8aR or 4aS,8aS enantiomers thereof, for preparing trans-(.+-.)-5-permissibly substituted-octahydropyrazolo (or oxazolo)[4,5-g]quinoline, 4aR,8aR or 4aS,8aS enantiomers thereof or for preparing trans-(.+-.)-6-permissibly-substituted octahydropyrimido[4,5-g]quinolines, a 5aR,9aR or 5aS,9aS enantiomer thereof said racemic intermediates being comprised of stereoisomers of the following formulas ##STR1## wherein R is H, alkyl or C.sub.1-3 straight-chain alkyl.
REFERENCES:
patent: 4198415 (1980-04-01), Kornfeld et al.
March, Advanced Organic Chemistry, 2nd Ed., McGraw-Hill (1977) pp. 346-347; 484-485; 710-711.
March, Advanced Organic Chemistry, 1st Ed., McGraw-Hill (1968), p. 337.
Buehler and Pearson, Survey of Organic Synthesis, 1970, pp. 2,3,4,5.
Bach et al., J. Med. Chem., 23, 481 (1980).
Johnson et al., J. Org. Chem., 33, 3207 (1968).
Momose et al., Chem. Pharm. Bull., 25, 1436 (1977) (Momose I).
Momose et al., ibid, 1797 (Monmose II).
Momose et al., ibid, 26, 620 (1978) (Momose III).
Bucci P. Ann
Eli Lilly and Company
Jiles Henry R.
Rowe James L.
Whale Arthur R.
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