Method of preparing particles suitable for tabletting into diagn

Details Method of preparing particles suitable for tabletting into diagn Method of preparing particles suitable for tabletting into diagn

1986-03-24

1989-04-11

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 6, 435 7, 435 11, 435 14, 435 15, 435 18, 435 17, 435 21, 435 25, 435 28, 4353171, 436 8, 436174, 436183, 424464, 424465, 34 9, 34 10, 264121, C12Q 100

Patent

active

048206270

ABSTRACT:
A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e.g., an enzyme, onto small particles, e.g., lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e.g., mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

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