Method of preparing oral dosage forms with a granulating composi

Details Method of preparing oral dosage forms with a granulating composi Method of preparing oral dosage forms with a granulating composi

1990-10-04

1991-12-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424439, 424441, 424461, 424462, 424465, 424466, 424493, 424494, 424495, 424497, 424498, A61K 926, A61K 946

Patent

active

050733770

ABSTRACT:
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.

REFERENCES:
patent: 4201756 (1980-05-01), Saeman et al.
patent: 4439453 (1984-03-01), Vogel
patent: 4582709 (1986-04-01), Peters et al.

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