Method of preparing optically pure (R)- or (S)-...

Details Method of preparing optically pure (R)- or (S)-... Method of preparing optically pure (R)- or (S)-...

2005-01-11

2005-01-11

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S487000

Reexamination Certificate

active

06841688

ABSTRACT:
Disclosed is a method of preparing an optically pure (R)- or (S)-tetrahydrofuranyl ketone. By such a method, (R)- or (S)-2-tetrahydrofuran amide is converted to (R)- or (S)-2-tetrahydrofuran nitrile through dehydration in the presence of a dehydrating agent and an amine base. Then, thus prepared (R)- or (S)-2-tetrahydrofuran nitrile is nucelophilic addition-reacted with a nucleophile, followed by hydrolyzing, thereby produce (R)- or (S)-tetrahydrofuranyl ketone having high optical purity, while minimizing production of other by-products.

REFERENCES:
patent: 3125584 (1964-03-01), Weis et al.
patent: WO 9201696 (1992-06-01), None
patent: wo03014106 (2003-02-01), None

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