Method of preparing optically active .beta.-(S)-aminoglutaric ac

Details Method of preparing optically active .beta.-(S)-aminoglutaric ac Method of preparing optically active .beta.-(S)-aminoglutaric ac

1982-06-14

1984-06-05

Warden, Robert J.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435850, C07B 2000, C12R 120

Patent

active

044528973

ABSTRACT:
The present invention provides a process for preparing a optically active .beta.-(S)-aminoglutaric acid monoalkyl ester of the formula: ##STR1## wherein R is a lower alkyl group having 1 to 4 carbon atoms, which comprises subjecting a .beta.-N-protected aminoglutaric acid dialkyl ester of the formula: ##STR2## wherein each R is as defined above and A is an easily removable protecting group, to an action of an enzyme produced by a microorganism belonging to the genera Flavobacterium, Achromobacter, Xanthomonas, Alcaligenes, Serratia, Gluconobacter, Chromobacterium and Acetobacter, to selectively hydrolyze only one of the two ester groups, and then removing the protecting group.

REFERENCES:
Hirokazu Kotani et al., Agricultural and Biological Chemistry, vol. 47, No. 6, pp. 1363-1365, 1983.
Masaji Ohno et al., Journal of American Chemical Society, vol. 103, pp. 2405-2406, 1981.

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