Method of preparing optically active alcohols which consist subs

Details Method of preparing optically active alcohols which consist subs Method of preparing optically active alcohols which consist subs

1992-06-15

1994-07-12

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549442, 549491, 556416, 556417, 556436, 558410, 558430, 558447, 558451, 564356, 564493, 568309, 568322, C07C20948

Patent

active

053290232

ABSTRACT:
The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 ##STR1## wherein R and A are as defined therein. The method comprises, which maintaining enantiomeric excess, converting an optically active cyanohydrin of formula 1 ##STR2## into optically active protected cyanohydrin of formula 2 ##STR3## converting the protected cyanohydrin of formula 2 into an optically active compound of formula 3 ##STR4## removing the protecting group B.

REFERENCES:
patent: 4611076 (1986-09-01), Dong et al.
patent: 4611077 (1986-09-01), Dong et al.
patent: 4859784 (1989-08-01), Effenberger et al.
Synthesis, Communications, Apr. 1981, pp. 270-272; Amouroux et al.
Bull. Chem. Soc., Japan, 59, (1986) pp. 893-895; Kobayashi, et al.
J. Org. Chem. 48, (1983), pp. 2294-2295; Elliott, et al.
Angew. Chem. 99, (1987), pp. 491-492; Effenberger, et al.
Tetrahedron Letters, 24, (1983), pp. 4075-4078; Krepski, et al.
Chemische Berichte, 64 (1931), pp. 427-434; Smith, et al.
Synthesis, (1986), 301-303; Krepski, et al.
Angew. Chem. 77 (1965), No. 24, p. 1139; Becker, et al.
Angew Chem. 99 (1987) pp. 503, 511 and 513 (3 pages presented) Hoffmann.

Affiliated with

Also associated with

Rating

Method of preparing optically active alcohols which consist subs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing optically active alcohols which consist subs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing optically active alcohols which consist subs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-397590