Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-11-18
2000-10-24
Huang, Evelyn Mei
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546192, C07D22122
Patent
active
061369802
ABSTRACT:
The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R, 6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-me thano-benzo[.alpha.]oxacin-9-ol] (BIII 277).
REFERENCES:
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patent: 4406904 (1983-09-01), Welle
patent: 5607941 (1997-03-01), Merz
patent: 5731318 (1998-03-01), Carter
Baltes Hanfried
Grauert Matthias
Merz Herbert
Boehringer Ingelheim KG
Devlin M-E. M.
Huang Evelyn Mei
Raymond R. P.
Stempel A. R.
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