Method of preparing norbenzomorphane as an intermediate in the p

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546192, C07D22122

Patent

active

061369802

ABSTRACT:
The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R, 6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-me thano-benzo[.alpha.]oxacin-9-ol] (BIII 277).

REFERENCES:
patent: 4012392 (1977-03-01), Akkerman
patent: 4293556 (1981-10-01), Merz
patent: 4406904 (1983-09-01), Welle
patent: 5607941 (1997-03-01), Merz
patent: 5731318 (1998-03-01), Carter

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