Method of preparing nanoparticle compositions containing charged

Details Method of preparing nanoparticle compositions containing charged Method of preparing nanoparticle compositions containing charged

1994-05-10

1995-11-28

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424484, 424493, 424497, A61K 914

Patent

active

054705835

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

REFERENCES:
patent: 4396630 (1983-08-01), Riedl et al.
patent: 4894234 (1990-01-01), Sharma et al.
patent: 4904479 (1990-02-01), Illum
patent: 5091188 (1992-02-01), Haynes
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5151264 (1992-09-01), Samain et al.
patent: 5188837 (1993-02-01), Domb

Affiliated with

Also associated with

Rating

Method of preparing nanoparticle compositions containing charged does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing nanoparticle compositions containing charged, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing nanoparticle compositions containing charged will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2011794