Method of preparing N.sub.1 -(2'-furanidyl)-5-substituted uracil

Details Method of preparing N.sub.1 -(2'-furanidyl)-5-substituted uracil Method of preparing N.sub.1 -(2'-furanidyl)-5-substituted uracil

1975-04-28

1977-08-02

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D23954

Patent

active

040395464

ABSTRACT:
A method of preparing N.sub.1 -(2'-furanidyl)-substituted uracils having the general formula ##STR1## where R is selected from the group consisting of hydrogen, halogen, and alkyl, consists in that 2,3-dihydrofuran is processed with anhydrous hydrogen chloride in a medium of an organic chlorinated aliphatic hydrocarbon solvent, and the thus formed product is reacted with 2,4-bis-(trimethylsilyloxy)-5R-substituted pyrimidines at a temperature not above 10.degree. C with subsequent isolation of the end product.

REFERENCES:
patent: 3912734 (1975-10-01), Giller et al.

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