Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-02-12
1994-09-20
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 5142295, 540468, 540546, 544 63, 548496, 548506, 548507, C07D20914, C07D20924, C07D49814, A61K 31535
Patent
active
053489497
ABSTRACT:
The invention relates to a method of preparing N-oxo-tetrahydro-.beta.-carbolines having formula 1. ##STR1## by an intramolecular ringclosure reaction of compounds of formula 2. ##STR2## wherein Z is an aldehyde function or acetal function, or is a functional group which can be converted into such a function during the ringclosure reaction.
The eudistomin derivatives within the group of compounds having formula 1 have strong antiviral and antitumour activity.
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Hermkens Peter H. H.
Kruse Cornelis G.
Scheeren Johan W.
Van Maarseveen Jan H.
Datlow P. I.
Duphar International Research B.V.
Shah Mukund J.
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