Method of preparing multi-modal anion-exchange ligands

Details Method of preparing multi-modal anion-exchange ligands Method of preparing multi-modal anion-exchange ligands

2008-01-22

2008-01-22

Therkorn, Ernest G. (Department: 1797)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S656000, C210S198200, C210S502100, C502S401000, C502S439000, C521S032000, C521S033000

Reexamination Certificate

active

07320754

ABSTRACT:
The invention relates to a method of preparing multi-modal anion-exchange ligands, which comprises providing a cyclic three-functional scaffold comprising an amine, a carbonyl and a thiol; optionally derivatisation of the amine of the scaffold to provide an anion-exchanging group and/or to protect the amine; and aminolysis to open up the derivative by adding a reagent comprising an amine coupled to a residue R in order to add said amine to the carbonyl carbon of the opened scaffold. The scaffold is advantageously homocysteine thiolactone. In one embodiment, the method comprises an additional step of immobilising the opened scaffold to a base matrix to provide a separation medium, such as a chromatography medium.

REFERENCES:
patent: 4837348 (1989-06-01), Stolowitz et al.
patent: 5945520 (1999-08-01), Burton et al.
patent: 7005071 (2006-02-01), Andersson et al.
patent: 7067059 (2006-06-01), Maloisel et al.
patent: 2004/0168983 (2004-09-01), Andersson et al.
patent: 2004/0238446 (2004-12-01), Maloisel et al.
patent: 2006/0027501 (2006-02-01), Andersson et al.
patent: 2006/0175237 (2006-08-01), Carlsson et al.
patent: 2006/0175258 (2006-08-01), Johansson et al.
patent: 2006/0188931 (2006-08-01), Maloisel et al.
patent: WO 97/29825 (1997-08-01), None
patent: WO 01/38227 (2001-05-01), None
patent: WO 02/053288 (2002-07-01), None
Feist, P., et al., “Sulfhydrylcellulose: A New Medium for Chromatography of Mercurated Polynucleotides”,Biochemistry, vol. 20, No. 15, 1981, p. 4243-4246.

Affiliated with

Also associated with

Rating

Method of preparing multi-modal anion-exchange ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing multi-modal anion-exchange ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing multi-modal anion-exchange ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2755935