Method of preparing monofluoromethyl ethers

Details Method of preparing monofluoromethyl ethers Method of preparing monofluoromethyl ethers

1997-11-21

1999-03-23

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568683, C07L 4100

Patent

active

058862390

ABSTRACT:
A method of preparing fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) and structurally related monofluoromethyl ethers in which the monochloromethyl ether precursor thereof is reacted with a sterically hindered tertiary amine hydrofluoride salt.

REFERENCES:
patent: 3683092 (1972-08-01), Regan et al.
patent: 3689571 (1972-09-01), Regan et al.
patent: 3897502 (1975-07-01), Russell et al.
patent: 4250334 (1981-02-01), Coon et al.
patent: 4314087 (1982-02-01), Radlick
patent: 4328376 (1982-05-01), Berger et al.
patent: 4469898 (1984-09-01), Coon et al.
patent: 4874901 (1989-10-01), Halpern et al.
Merck, citation for Sevoflurane, Merck Number 8621.
Bensoam et al. Tetrahedron Lett. (1979), (4), 353-356 (Abstract only provided).
Okazaki et al., Journal of Fluorine Chemistry, 4 (1974) 387-397.
Franz, Journal of Fluorine Chemistry, 15 (1980) 423-434.
Halpern, Organofluorine Chemistry: Principles and Commercial Applications, Banks et al. 1994, pp. 543-554.

Affiliated with

Also associated with

Rating

Method of preparing monofluoromethyl ethers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing monofluoromethyl ethers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing monofluoromethyl ethers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2127433