Method of preparing mixed formulation of sustained release...

Details Method of preparing mixed formulation of sustained release... Method of preparing mixed formulation of sustained release...

2008-07-15

2008-07-15

Kennedy, Sharon E. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

Reexamination Certificate

active

07399486

ABSTRACT:
Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.

REFERENCES:
patent: 4360598 (1982-11-01), Otagiri et al.
patent: 4554887 (1985-11-01), Yoakam et al.
patent: 4777033 (1988-10-01), Ikura et al.
patent: 4798694 (1989-01-01), Sugata et al.
patent: 5489439 (1996-02-01), Bola
patent: 5723269 (1998-03-01), Akagi et al.
patent: 6451349 (2002-09-01), Robinson et al.
patent: 2004/0240311 (2004-12-01), Hashiba

Affiliated with

Also associated with

Rating

Method of preparing mixed formulation of sustained release... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing mixed formulation of sustained release..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing mixed formulation of sustained release... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2780569