Method of preparing methyl ester and its hydrochloride

Details Method of preparing methyl ester and its hydrochloride Method of preparing methyl ester and its hydrochloride

1984-05-17

1986-10-21

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

26099821, C07C10102

Patent

active

046186956

ABSTRACT:
A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balance) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding the solution at 0.degree. to 60.degree. C. to effect intramolecular ester exchange reaction and crystallize out the formed .alpha.-L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating the hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali, is disclosed.

REFERENCES:
patent: 3798207 (1974-03-01), Ariyoshi et al.
Mitsubishi, Derwent Abst., No. 16297v/09, J4 8096-557, Mar. 22, 1972.
Chemical Abstracts, 101, 763(1984).

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