Method of preparing medical aerosol formulations including drug

Details Method of preparing medical aerosol formulations including drug Method of preparing medical aerosol formulations including drug

1992-01-30

1994-03-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 43, 424450, 514937, A61K 912

Patent

active

052924998

ABSTRACT:
The present invention provides a method for the production of medicinal aerosol compositions which are made up of a homogenous solution of aerosol propellants, a surfactant and a pharmaceutically active compound, where the process comprises purifying the surfactant, removing the water from the surfactant, and dispersing the surfactant in an aerosol propellant with a hydrophilic pharmaceutical composition and a controlled amount of water. The present invention also provides medicinal aerosol compositions produced by this method which are a homogenous solution of the pharmaceutically active compound contained in reverse micelles made up of the surfactant; and methods of using the medicinal aerosols to provide an effective amount of a therapeutic agent.

REFERENCES:
patent: 4814161 (1989-03-01), Jinks
patent: 5230884 (1993-07-01), Evans et al.
P. L. Luisi et al. (1988). Biochimica et Biophysica Acta, vol. 947, PP 209-246.
Byron, P. R. (1990). Respiratory Drug Delivery. CRC Press, Inc., pp. 249-257.
Evans, R. M. et al. (1988). Journal of Pharmaccy & Pharmacology, vol. 40, p. 7P.

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