Method of preparing liposomes and products produced thereby

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424 4, 424 5, 424450, 424491, 424493, 514 3, 514 31, A61K 916, A61K 3722, A61K 950

Patent

active

047449896

ABSTRACT:
A method is provided for preparing stable liposome precursors in the form of a water-soluble carrier material coated with a predetermined amount of a thin film of liposome components, which method includes the steps of dissolving at least one liposome-forming amphipathic lipid, optionally, at least one biologically active compound, and, optionally, at least one adjuvant in a suitable organic solvent and employing the resulting organic solution to coat a suitable water-soluble carrier material to form thin film of predetermined amount of liposome components thereon. Upon exposing the coated carrier material to water, the thin films of liposome components hydrate and the carrier material dissolves to give liposome preparations.

REFERENCES:
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4247411 (1981-01-01), Vanlerberghe et al.
patent: 4311712 (1982-01-01), Evans et al.
patent: 4508703 (1985-04-01), Redziniak et al.
Ryman, B. E., "The Use of Liposomes as Carriers of Drugs and Other Cell-Modifying Molecules," Proc. 6th Int'l. Congr. Pharmacol. 5, 91 (1976).

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