Method of preparing lipid structures

Details Method of preparing lipid structures Method of preparing lipid structures

1988-05-17

1991-02-19

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 424450, A61K 9133, A61K 9127, B01J 1312

Patent

active

049942131

ABSTRACT:
A method of forming lipid structures, such as liposomes is disclosed. Lipids are dissolved in a solvent system containing a water-miscible solvent, such as ethanol, and an aqueous medium. The water:solvent ratio is raised by removing water and solvent in a reverse osmosis system, and replacing lost solvent with added aqueous medium, preferably at a rate which just balances volume loss by reverse osmosis. In one embodiment, the method is used to produce uniform-size liposomes.

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patent: 4622188 (1986-11-01), Adamich et al.
patent: 4731210 (1988-03-01), Weder et al.
patent: 4752425 (1988-06-01), Martin et al.
Batzri et al.: "Single Bilayer Liposomes . . . ", Biochim. Biophys. Acta., vol. 298, pp. 1015-1019, 1973.
Kremer et al.: "Vesicles of Variable Diameter . . . ", Biochemistry, vol. 16, No. 17, 1977, pp. 3932-3935.

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