Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic

Details Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic

1995-09-07

1997-04-01

Conrad, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C22908

Patent

active

056167911

ABSTRACT:
The present invention provides a method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylamide which is less expensive and more efficient than previous methods using N-protected-L-aspartic anhydride.

REFERENCES:
patent: 4508180 (1985-04-01), Yamatani et al.
patent: 4550180 (1985-10-01), Takemoto et al.
patent: 5286509 (1994-02-01), D'Angelo et al.
Chemical Abstracts, vol. 121, No. 11, Sep. 12, 1994, AN-134755a, I.Y. Lee, et al., "Synthesis of an Aspartame Precursor Using Thermolysin in Organic Two-Phase System".

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