Method of preparing ketoprofen

Details Method of preparing ketoprofen Method of preparing ketoprofen

1988-07-29

1989-07-04

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548486, 562433, 562491, C07C 5976

Patent

active

048452815

ABSTRACT:
A method of preparing ketoprofen by reacting aniline with a halide of an alpha-halogen propionic acid, benzylation of 3-methyl-2-indolinone, alkaline hydrolysis of 5-benzyl-3-methyl-2-indolinone, deamination of 2-(3-benzyl-6-aminophenyl)propionic acid and oxidation of 2-(3-benzylphenyl)propionic acid.

REFERENCES:
patent: 1711164 (1929-04-01), Adams
patent: 3621037 (1971-11-01), Thials et al.
patent: 4058559 (1977-11-01), Jones
patent: 4695648 (1982-09-01), Aghack
patent: 4714776 (1982-12-01), Bell

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