Method of preparing granules of dipeptide

Details Method of preparing granules of dipeptide Method of preparing granules of dipeptide

1993-08-30

1994-10-25

Eley, Timothy V.

Solid material comminution or disintegration

Processes

With classifying or separating of material

241 22, B02C 700

Patent

active

053581865

ABSTRACT:
In producing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a particle size of falling within a determined particle size range by compaction granulation, formation of fine powdery .alpha.-APM is prevented by breaking the compacted .alpha.-APM so that the one-pass yield of the granules is elevated and the sieving efficiency is elevated. In a method of preparing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester by compaction granulation of the ester singly or along with a vehicle of not more than the same amount of the ester, after the compaction or after having roughly broken the compacted material, the material is broken down so as to pass through a screen or perforated plate having pores with a diameter falling within the range of from 1 mm to 10 mm and then further broken and classified.

REFERENCES:
patent: 5110056 (1992-05-01), Blasczyk et al.
patent: 5111998 (1992-05-01), Kanda et al.
European Search Report, EP 9311 3913, Apr. 29, 1994.

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