Method of preparing gas-filled polymer matrix microparticles...

Details Method of preparing gas-filled polymer matrix microparticles... Method of preparing gas-filled polymer matrix microparticles...

2005-07-19

2005-07-19

Hartley, Michael (Department: 1616)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

C424S501000, C516S011000, C516S077000

Reexamination Certificate

active

06919068

ABSTRACT:
A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation. The resulting porous microparticles can receive a gas and be used as an ultrasound contrast agent.

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patent: WO 98/48783 (1998-11-01), None

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