Method of preparing fluorescently labeled microbeads

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...

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428407, 25230135, 523200, 526909, C08F 832, C08F 2032

Patent

active

046096892

ABSTRACT:
Highly uniform polymeric microbeads of a predetermined size, preferably having an attached fluorescent label on the surface, are prepared by causing seed particles to swell by absorption of a plurality of low molecular weight substances, at least one of which is a monomer having a reactive functional group. After absorption, the monomer is internally polymerized, and the reactive functional group is preferably reacted with a polyfunctional spacing agent thereby to provide a second reactive functional group. The latter is then reacted with a fluorescent label to provide the labeled microbead.

REFERENCES:
patent: 4206094 (1980-06-01), Yen et al.
patent: 4247434 (1981-01-01), Vanderhoff et al.
patent: 4332694 (1982-06-01), Kalal et al.
patent: 4336173 (1982-06-01), Ugelstad

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