Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(

Details Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2( Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(

1994-04-28

1995-06-13

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26108

Patent

active

054244447

ABSTRACT:
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

REFERENCES:
Tetrahedron vol. 49, No. 11, pp. 2317-2324, A Synthesis of (-) . . . Cycloaddition..sup.1 , Hassner et al., 1993.

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