Method of preparing dl 6-phenyl-2,3,5,6-tetrahydroimidazo-[2,1-b

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D51304

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041071700

ABSTRACT:
An improved method of preparing acid addition salts of dl 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (dl-tetramisole) by reacting dl-3-(.beta.-hydroxyphenethyl)-2-iminothiazolidine or an acid-addition salt thereof, with a mixture of concentrated hydrochloric acid and concentrated sulfuric acid to obtain dl 3-(.beta.-chlorophenethyl)-2-iminothiazolidine acid-addition salt, treating this compound with aqueous alkali to obtain dl 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole free base, and converting the latter compound to dl 6-phenyl-2,3,5,6-tetrahydroimidazo [2,1-b]thiazole acid-addition salts in a highly purified state. The products are useful as anthelmintics.

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Harrison, et al., Compendium of Organic Synthetic Reactions (1971), pp. 331-332.
Theilheimer, "Synthetic Methods, " 1968, p. 273, set 590.

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