Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-02-14
1978-08-15
Daus, Donald G.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07D51304
Patent
active
041071700
ABSTRACT:
An improved method of preparing acid addition salts of dl 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (dl-tetramisole) by reacting dl-3-(.beta.-hydroxyphenethyl)-2-iminothiazolidine or an acid-addition salt thereof, with a mixture of concentrated hydrochloric acid and concentrated sulfuric acid to obtain dl 3-(.beta.-chlorophenethyl)-2-iminothiazolidine acid-addition salt, treating this compound with aqueous alkali to obtain dl 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole free base, and converting the latter compound to dl 6-phenyl-2,3,5,6-tetrahydroimidazo [2,1-b]thiazole acid-addition salts in a highly purified state. The products are useful as anthelmintics.
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Harrison, et al., Compendium of Organic Synthetic Reactions (1971), pp. 331-332.
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American Cyanamid Company
Daus Donald G.
Kline Harry H.
Wheeler David E.
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