Method of preparing diphtheria immunotoxins

Details Method of preparing diphtheria immunotoxins Method of preparing diphtheria immunotoxins

1989-01-25

1993-05-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 855, 424 858, 5303881, 53038822, 5303901, 530409, 530412, 530417, 530820, 435 691, 436548, A61K 3900, C07K 300

Patent

active

052080218

ABSTRACT:
A potent and specific immunotoxin is prepared by coupling an inactivated diphteria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.

REFERENCES:
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patent: 4956453 (1990-09-01), Bjorn et al.
patent: 4981979 (1991-01-01), Sivam
Colombatti et al, The Journal of Biological Chemistry, vol. 261, No. 7, pp. 3030-3035, Mar. 5, 1986.
Youle et al, The Journal of Immunology, vol. 136, No. 1, pp. 93-98, Jan. 1, 1986.
Akiyama et al, Cancer Research, vol. 45, pp. 1005-1007, 1985.
Zovickian et al, J. Neurosurg., vol. 68, pp. 767-774 (1988).
Neville, Jr. et al, The Journal of Biological Chemistry, vol. 264, No. 25, pp. 14653-14661 (1989).
Laird et al, Journal of Virology, vol. 19, No. 1, pp. 220-227 (1976).
Annual Progress Report, U.S. Army Medical Research Institute of Infectious Diseases, pp. 95-96 (1981).

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