Method of preparing D-propoxyphene

Details Method of preparing D-propoxyphene Method of preparing D-propoxyphene

1992-03-19

1994-05-17

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6702

Patent

active

053129709

ABSTRACT:
D-propoxyphene can be prepared by reacting d-oxyphene and propionic anhydride. Preferably, an excess of propionic anhydride is used. The reaction easily proceeds at temperatures of 70.degree. to 80.degree. C. and produces yields exceeding 95 percent of theory. The free base d-propoxyphene can easily be converted in high yields to its hydrochloride or napsylate salts, both analgesics.

REFERENCES:
patent: 2728779 (1955-12-01), Pohland
patent: 3065261 (1962-11-01), Stephens
patent: 3487469 (1969-12-01), Marxer
patent: 3728379 (1973-04-01), Stephens
patent: 4661625 (1987-04-01), White
Pohland and Sullivan, J. Am. Chem. Soc. 75:4458-4461 (1953).
Pohland and Sullivan, J. Am. Chem. Soc. 77:3400-3401 (1953).
Pohland, Peters, and Sullivan, J. Organic Chem. 28:2483-2484 (1963).

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