Method of preparing D-luciferin derivatives

Details Method of preparing D-luciferin derivatives Method of preparing D-luciferin derivatives

1993-05-14

1994-12-20

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving luciferase

435 4, 435 25, 435 772, 435 23, 540469, 548178, 536 2626, 530330, C12Q 166, C12Q 100, A61K 3702, C07D27762

Patent

active

053745345

ABSTRACT:
A method of preparing a 6-substituted D-luciferin ester suitable for use in the determination of pesticides by a bioluminescence method. The 6-substituted D-luciferin esters, such as 6-D-luciferin acetate, are prepared in a liquid solvent containing N-acetyl imidazole with D-luciferin and recovering as the reaction product 6-D-luciferin acetate.

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Toya, Y. et al, "Improved synthetic methods of firefly luciferin derivatives for use in bioluminescent analysis of hydrolytic enzymes; carboxylic esterase and alkaline phosphatase", Bulletin of the Chemical Society Of Japan, vol. 65, No. 10, Oct. 1992 pp. 2604-2610.
Kamijo, T. et al, "1-acyl-3-substituted imidazolium salts as highly reactive acylating agents", Chemical And Pharmaceutical Bulletin, vol. 30, No. 10, Oct. 1992, pp. 4242-4244.

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