Method of preparing crosslinked biomaterial compositions for use

Details Method of preparing crosslinked biomaterial compositions for use Method of preparing crosslinked biomaterial compositions for use

1994-08-08

1996-08-27

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

523113, 424423, C08G 6349, C08G 6391

Patent

active

055501877

ABSTRACT:
The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.

REFERENCES:
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5292802 (1994-03-01), Rhee et al.
patent: 5306500 (1994-04-01), Rhee et al.
patent: 5328955 (1994-07-01), Rhee et al.

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