Method of preparing collagen dressing sheet material

Plastic and nonmetallic article shaping or treating: processes – With step of cooling to a temperature of zero degrees c. or...

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264101, 264236, 264320, 264347, 128156, 128DIG8, C08L 8900, B29B 1304

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049485407

ABSTRACT:
A mechanically stable, conformable collagen wound dressing sheet material is fabricated by lyophilizing (freeze-drying) a collagen composition and compressing the porous pad thus produced at a pressure between about 15,000-30,000 p.s.i. The sheet material thus produced may also be treated with optional dehydrothermal crosslinking known in the art. In addition to mechanical stability and conformability, the sheet material demonstrates high absorptivity, i.e., about 15-20 times its weight in isotonic saline, making it highly useful as a medical or surgical dressing or as a carrier for other medicaments such as antibiotics. The sheet material may be impregnated with thrombin.

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