Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1978-03-20
1981-01-27
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
23230B, 424 11, 424 13, G01N 3348, G01N 3368
Patent
active
042475368
ABSTRACT:
A set of four cell suspensions containing erythrocytes monospecifically sensitized with IgG, IgM, C3, and C4. The suspensions provide control cells to determine the purity and strength of the antibodies to these immunoglobins or complement components contained in antisera used for clinical testing. Strict control of the pH, temperature, and EDTA concentration of a solution to which blood is added allows for the elective production of C3- or C4-sensitized cells. Selecting a serum with IgG or IgM antibodies and inactivating undesired proteins permits the production IgG- or IgM-sensitized cells. The resultant cells have agglutination reaction strengths of about 2-4+. Erythrocytes from humans or other animals may undergo the monospecific sensitization. Other human proteins, such as IgA or C5, and plasma proteins from other animals may similarly be attached monospecifically to red blood cells.
REFERENCES:
patent: 4092114 (1978-05-01), Buck
Frommel, Immunol., vol. 13, 1967, pp. 501-508.
LoBuglio, Science, vol. 158, Dec. 22, 1967, pp. 1582-1585.
Huber, Science, vol. 162, Dec. 13, 1968, pp. 1281-1283.
Huber, Fed. Proc., vol. 29, 1970, Ab. No. 2109.
Nusbacher, The J. of Immunol., vol. 108, 1972, pp. 803-902.
Garratty, Transfusion, vol. 16, 1976, pp. 297-306.
Moore, Transfusion, vol. 14, 1974, pp. 416-424.
Kwapinski, Method of Immunochem & Immunol. Res. Intersci., Pub. N.Y., 1972, pp. 245-247, 416-419, 422-429, 430-439.
Rosse et al., The J. of Clin. Invst., vol 53, 1974, pp. 31-43.
Freedman et al., Vox. Sang., vol. 31, 1976, pp. 241-257.
Bolotin et al., Biochemistry, vol. 16, 1977, pp. 2008-2015.
Logue et al., The J. of Clin. Invst., vol. 52, 1973, pp. 493-501.
Schreiber et al., The J. of Clin. Invst., vol 51, 1972, pp. 575-589.
Gilliland et al., The J. of Clin. Invst., vol. 49, 1970, pp. 898-906. C4-sensitized
Carro Jose
Fruitstone Mitchell J.
Pixton Betty G.
American Hospital Supply Corporation
Fagelson Anna P.
Figg Edward A.
Hartenberger Robert E.
LandOfFree
Method of preparing C3-sensitized erythrocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of preparing C3-sensitized erythrocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing C3-sensitized erythrocytes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1181664