Method of preparing bioerodible polymers having pH sensitivity i

Details Method of preparing bioerodible polymers having pH sensitivity i Method of preparing bioerodible polymers having pH sensitivity i

1988-07-01

1989-08-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

523105, 528392, 424426, 514950, 514964, 514866, A61K 922, A61K 31765, C08G 6528

Patent

active

048551325

ABSTRACT:
Biodegradible polymers are provided which may contain a biologically active substance, e.g. a drug such as insulin, which is released over a period of time as the polymer erodes when in contact with a body fluid. The polymer contains an amine functionality whereby it erodes faster at low acid pH's than at higher acid pH's. As an example, the polymer may contain insulin and may contain or may have an encapsulating hydrogel containing glucose oxidase. As the blood sugar level of a diabetic person rises, e.g., after a meal, glucose diffuses into the polymer or hydrogel and is converted to gluconic acid which lowers the pH, and accelerates erosion and the release of insulin.

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