Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1979-09-10
1981-06-30
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Lymphokine
260112B, 424 86, 424 87, A61K 39395, A61K 3900
Patent
active
042762839
ABSTRACT:
A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation.
REFERENCES:
patent: 3415804 (1968-12-01), Polsom
patent: 3763135 (1973-10-01), Shanbrom et al.
patent: 4093606 (1978-06-01), Coval
patent: 4126605 (1978-11-01), Schneider et al.
patent: 4165370 (1979-08-01), Coval
Eibl Martha
Linnau Yendra
Schwarz Otto
"Immuno" Aktiengesellschaft fur chemisch-medizinische Produkte
Hazel Blondel
Phillips Delbert R.
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