Method of preparing an animal model for interstitial pneumonia

Details Method of preparing an animal model for interstitial pneumonia Method of preparing an animal model for interstitial pneumonia

2005-05-31

2005-05-31

Spector, Lorraine (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C514S002600, C530S351000

Reexamination Certificate

active

06899869

ABSTRACT:
A method of preparing an animal model of interstitial pneumonia by administering interleukin 18 and interleukin 2. Because the animal model resembles closely human clinical findings, it is precisely capable of screening a drug, which can be expected to be clinically useful.

REFERENCES:
Arai et al. Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo. J. Interferon & Cytokine Res., Feb. 2000, 20 (2):217-24.*
Bohn et al. IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol., 1998, 160:299-307.*
Taniguchi et al. Characterization of anti-human IL-18/IGIF monoclonal antibodies and their application in the measurement of human IL-18 by ELISA. 1997. J. Immuno. Meth., 206:107-113.*
Saito et al.; Elevated Local Production of Neopterin From Alveolar Macrophages in Patients with Internal Lung Diseases; Gen. Pharmac. vol. 27, No. 3, pp. 483-486, 1996. See PCT search report.
Tada et al.; The Significance of Soluble IL-2 Receptors in Rheumatoid Arthritis with Interstitial Pneumonia, Allergy, 41 (3), pp. 428-433, 1992. Partial English translation. See PCT search report.

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