Method of preparing amino alcohols

Details Method of preparing amino alcohols Method of preparing amino alcohols

1990-08-07

1991-10-01

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564489, 564494, C07C20934

Patent

active

050535455

ABSTRACT:
A method of preparing an amino alcohol of the formula ##STR1## where R.sub.1 is H, lower alkyl or R.sub.2, R.sub.2 is R.sub.3 CHOH in which R.sub.3 is H, alkyl or aryl. R.sub.3 preferably is hydrogen, lower alkyl or monocyclic aryl such as phenyl. The inventive method involves the reaction of halonitroalcohol with hydrogen in the presence of methanol, a suitable buffering agent such as ammonia, and a hydrogenation catalyst to form amino alcohol salt, neutralizing the amino alcohol salt, and recovering the resultant amino alcohol.

REFERENCES:
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patent: 2587572 (1952-02-01), Tryon
patent: 3564057 (1971-02-01), Tindall
patent: 4221740 (1980-09-01), Pfeiffer
Iguchi, Y, "A process for the preparation of 2-amino-1,3-poopanectiol", CA 108, 166968v (1988).
Iio, A et a, "Preparation of Aminoalcohols as drug intermediates", CA 112, 98019s (1990).

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