Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es

Details Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es

1992-05-20

1993-11-30

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 40, 560 38, C07C22900

Patent

active

052667197

ABSTRACT:
In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. and neutralization is effected with stirring to the isoelectric point of .alpha.-APM; or after the neutralization, the neutralized liquid is heated. The neutralized liquid is thereafter cooled with or without stirring so that crystals of .alpha.-APM are precipitated.

REFERENCES:
Chemical Abstracts, 66803b, vol. 79, No. 11, Sep. 17, 1973, p. 484, & Bull. Chem. Soc. Jap., (1973), 46(6), pp. 1893-1895.
Y. Ariyoshi, et al., "Synthesis of a Sweet Peptide, .alpha.-Aspartyl-L-Phenyl-Alanine Methyl Ester, Without the use of Protecting Groups".
Chemical Abstracts, 6056z, vol. 85, No. 1, (Jul. 5, 1976), p. 492, & JP-A2-76-13 737, Feb. 3, 1976, N. Uchiyama, et al., ".alpha.-Aspartyl-L-Phenylalanine Lower Alkyl Esters".
Chemical Abstracts, 136391g, vol. 87, No. 17, Oct. 24, (1977), p. 800, & JP-A2-76-95 017, Aug. 20, 1976, M. Fujino, et al., "Aspartyl Dipeptide Esters".

Affiliated with

Also associated with

Rating

Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2098033