Method of preparing alpha-arylalkanoic esters

Details Method of preparing alpha-arylalkanoic esters Method of preparing alpha-arylalkanoic esters

1986-07-21

1989-06-27

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 55, 560 66, 560 9, C07C 6976

Patent

active

048431699

ABSTRACT:
Alpha-arylalkanoic esters are prepared by reacting a trivalent iodine compound of the formula ##STR1## wherein Ar is an aromatic hydrogen and X and Y each represent a group which can be removed as an anion, with a carbonyl compound of the formula ##STR2## where Ar.sup.1 is an aromatic hydrocarbon, R is a hydrogen atom or an alkyl group, and R.sup.1 is a hydrogen atom or an alkyl group, in the presence of an orthocarboxylic ester having the general formula ZC(OR.sup.2).sub.3, wherein R.sup.2 is an alkyl group and Z is a hydrogen atom or an alkyl group; the reaction being carried out in the presence of sulfuric acid in an amount from about 0.2 to about 0.8 mole per mole of the carbonyl compound.

REFERENCES:
patent: 4316046 (1982-02-01), Costa
Tamura et al., Synthesis, pp. 231-232 (Mar. 1984).
A. Goosen and C. W. McCleland, J. Chem. Soc., Chem. Commun., pp. 1311-1312 (1982).
Y. Hamada and T. Shioiri, Tetrahedron Lett., 23(2), pp. 235-236 (1982).
S. D. Higgins and C. B. Thomas, J. Chem. Soc., Perkin Trans. I, pp. 235-242 (1982).
K. Fujii et al., Synthesis, pp. 456-457 (1982).
B. Myrboh et al., Synthesis, pp. 126-127 (1981).
G. Tsuchihashi et al., Tetrahedron Lett., 22(43), pp. 4305-4308 (1981).
T. Shioiri and N. Kawai, J. Org. Chem., 43(14), pp. 2936-2938 (1978).
A. McKillop et al., J. Am. Chem. Soc., 95(10), pp. 3340-3343 (1973).

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