Method of preparing .alpha.-aromatic propionic acids and interme

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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568328, 549 79, 548494, 548170, 548572, 562490, 562465, 562433, 562427, 562462, 562496, 560 9, 560152, 546238, C07D21134, C07D33302, C07D33324, C07D27760

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045770255

ABSTRACT:
A method for the preparation of an ester of .alpha.-thio-.alpha.-aromatic propionic acid derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl, phenyl or benzothiazolyl, R.sup.2 is alkyl and Ar is an aromatic substituent.
The method comprises reacting an ester of .alpha.-chloro-.alpha.-thiopropionic acid of the formula: ##STR2## with an aromatic compound of the formula ARH, in the presence of a Lewis acid. The method provides good reactivity and positional selectivity in the Friedel-Crafts reaction. Many esters of the formula (2) are useful as pharmaceuticals, agricultural chemicals, perfumes or their intermediates.

REFERENCES:
patent: 2642429 (1953-06-01), Clinton et al.

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