Method of preparing alpha-1-proteinase inhibitor

Details Method of preparing alpha-1-proteinase inhibitor Method of preparing alpha-1-proteinase inhibitor

1983-01-27

1984-03-27

Kight, III, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, 260112R, C07G 700

Patent

active

044393580

ABSTRACT:
A method is disclosed for separating alpha-1-proteinase inhibitor from a blood plasma fraction particularly from the Cohn fractionation scheme. An aqueous solution of the blood plasma fraction is held at a pH of about 6.5-8.5, and a temperature of about 2.degree.-50.degree. C. for a period of about 0.2-24 hours and then mixed with a poly-condensed polyglycol. The mixture may be held at a temperature of about 2.degree.-10.degree. C. for a period of about 1-24 hours. Next, the pH of the mixture is adjusted to selectively precipitate unwanted proteins from the solution of alpha-1-proteinase inhibitor which is separated from the solution and purified further. The amount of poly-condensed polyglycol and the pH of the mixture are selected accordingly.

REFERENCES:
patent: 4096136 (1978-06-01), Ayers et al.
patent: 4110077 (1978-08-01), Klein et al.
patent: 4379087 (1983-04-01), Coan et al.

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