Method of preparing activated protein C

Details Method of preparing activated protein C Method of preparing activated protein C

1992-06-17

1994-07-19

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 681, 435 23, 530380, C12N 900

Patent

active

053309073

ABSTRACT:
To produce activated protein C, protein C is treated with plasmin. Activation is effected in a quick and simple manner. Contamination of the activated protein C with thrombin is avoided.

REFERENCES:
patent: 4489403 (1989-07-01), Stocker et al.
Ehrlich et al., 1990, EMBO Journal, 9, 2367-2373, "Recombinant Protein C Derivatives . . . ".
Cho et al., 1984, Active-Site Mapping . . . , Biochemistry, 23:647.
Loscalzo, J., 1990, (Apr.), An Overview of Thrombolytic Agents, Chest 97(4):1175-1195.
Comp et al., 1982, Activation of Protein C in vivo, J. Clin. Invest., vol. 70:127-134.
G. Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, vol. 256, Aug. 7, 1975, pp. 495-497.
O. Taby et al., "Inhibition of Activated Protein C by Aprotinin and the Use of the Insolubilized Inhibitor for its Purification", Thrombosis Research, vol. 59, 1990, pp. 27-35.
Bajaj et al., "A Procedure For Isolation Of Human Protein C and Protein S", Preparative Biochemistry, 13(3), 191-214, 1983.
Henriksson et al., "Effect of Leukocytes, Plasmin and Thrombin on Clotting Factors", Thrombosis Research, 16:301-312, 1979.

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