Method of preparing a thromboplastin extract

Details Method of preparing a thromboplastin extract Method of preparing a thromboplastin extract

1991-07-22

1993-10-19

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Nervous system

424583, 514 2, 514 21, 530381, 435 13, A61K 3530

Patent

active

052543501

ABSTRACT:
A process for preparing a thromboplastin extract including extracting a powdered thromboplastin source in an aqueous solution having a metal ion chelator, and separating the powder in solution into sedimented powder and supernatant thromboplastin extract is disclosed. The supernatant thromboplastin extract is mixed with calcium ions, and may be mixed with one or more of a stabilizer and a preservative, to prepare thromboplastin reagent.

REFERENCES:
patent: 3522148 (1970-07-01), Adam, Jr. et al.
patent: 4416812 (1983-11-01), Becker et al.
patent: 4784944 (1988-11-01), Kolde
Hubbard et al., BA82:20346, 1986.
Hubbard et al., "Inhibition of Tissue Thromboplastin-Mediated Blood Coagulation," Thrombosis Research 42:489-498 (1986).

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